The lack of sleep can have a serious effect on your behaviour and brain.
After a certain time of being active, the sleep neurons in your brain start to get tired and this can affect your brains behaviour in ways such as, trouble concentrating, difficulty focusing and having trouble thinking straight and remembering things.
With the lack of sleep your temporal lobe, which is associated with the processing of language, can be largely affected. When asleep there is no activity in this lobe, so after an excessive lack of sleep this region can become slack and this results in slurred speech and other affects.
Research tells us that after going without sleep for 24 hours it is more dangerous driving than driving drunk. Other effects on your brain and behaviour can be memory lapses, hallucinations and even can cause experience depersonalization which is where you do not feel like you are in reality, more like you are living in a dream.
It is also said in research that after one night of bad sleep your dopamine (the "pleasure" neurotransmitter) brain levels increase. Studies have also found that the lack of sleep may heighten your likelihood of developing Alzheimer's diseases.